ANTIGENICITY STUDY OF CEFPIROME SULFATE
نویسندگان
چکیده
منابع مشابه
Stability of Cefpirome Sulfate in Aqueous Solutions.
The influence of pH on the stability of cefpirome sulfate was investigated in the pH range of 0.44 - 13.00. The degradation of cefpirome sulfate as a result of hydrolysis was a pseudo-first-order reaction. General acid-base hydrolysis of cefpirome sulfate was not observed. In the solutions of hydrochloric acid, sodium hydroxide, acetate, borate and phosphate buffer, k(obs) = k(pH) because speci...
متن کاملDevelopment and validation of stability-indicating HPLC method for determination of cefpirome sulfate.
The stability-indicating LC assay method was developed and validated for quantitative determination of cefpirome sulfate (CPS) in the presence of degradation products formed during the forced degradation studies. An isocratic HPLC method was developed with Lichrospher RP-18 column, 5 μm particle size, 125 mm x 4 mm column and 12 mM ammonium acetate-acetonitrile (90 : 10 v/v) as a mobile phase. ...
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چکیده ندارد.
15 صفحه اولSYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS IN THE CEFPIROME SERIES III. 7a-METHOXY AND 7a-FORMAMIDO ANALOGUES OF CEFPIROME
7«-Methoxy and 7a-formamido derivatives of cefpirome (HR 810) have been synthesized and tested in comparison with cefpirome and some analogues 1 against aerobic and anaerobic bacteria. Cefpirome and analogues 1 have good activity against Gram-positive and only limited activity against Gram-negative anaerobic bacteria. 7a-Methoxy derivatives 2 show only a slight improvement of activity against G...
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ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 1990
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.15.supplementiii_129